Preheat your oven to 375 degrees Fahrenheit.
Boil salted water, and cook pasta for 8-10 minutes until al dente. Drain.
Melt 1/3 cup of butter in a sizable saucepan over medium heat.
Whisk in flour until smooth and well combined.
Gradually whisk in whole milk in a thin, steady stream.
Add salt and nutmeg. Cook for 7-8 minutes until thickened, whisking frequently.
In a large bowl, combine mozzarella, asiago, fontina, and cheddar cheeses.
Reserve 2 1/3 cups cheese mixture for topping.
Add the remaining cheese mixture to the milk mixture, handful by handful. Whisk smoothly.
Blend in Romano cheese until well combined.
Stir in cooked pasta and truffle oil until well mixed.
Spread the mixture in a baking dish or individual baking dish.
Spread reserved cheeses on top of the mixture.
In a large skillet over medium-high heat, melt the remaining 1/3 cup butter.
Add Italian seasoning and garlic. Stir constantly, heat garlic for 30 seconds.
Stir and coat bread cubes, spread over pasta.
Indulge in the comfort of Macaroni Grill Mac And Cheese at home!